Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting

Damian Maciejewski; Piotr Pieniazek; Lukasz Tekieli; Piotr Paluszek; Tadeusz Przewlocki; Tomasz Tomaszewski; Roman Machnik; Mariusz Trystula; Jacek Legutko; Anna Kablak-Ziembicka

doi:10.5114/aic.2019.87887

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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abstract:

Original paper

Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting

Damian R. Maciejewski

¹

,

Piotr Pieniazek

^{1, 2, 3}

,

Lukasz Tekieli

¹

,

Piotr Paluszek

²

,

Tadeusz Przewlocki

^{1, 2, 3}

,

Tomasz Tomaszewski

⁴

,

Roman Machnik

²

,

Mariusz Trystula

²

,

Jacek Legutko

¹

,

Anna Kablak-Ziembicka

¹

Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
Department of Vascular Surgery and Endovascular Interventions, John Paul II Hospital, Krakow, Poland
Department of Cardiac and Vascular Diseases, Jagiellonian University, John Paul II Hospital, Krakow, Poland
Department of Neurology and Stroke Unit, John Paul II Hospital, Krakow, Poland

Adv Interv Cardiol 2019; 15, 3 (57): 328–337

DOI: https://doi.org/10.5114/aic.2019.87887

Online publish date: 2019/09/18

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AMA

Maciejewski DR, Pieniazek P, Tekieli L, et al. Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2019;15(3):328-337. doi:10.5114/aic.2019.87887.

APA

Maciejewski, D. R., Pieniazek, P., Tekieli, L., Paluszek, P., Przewlocki, T.,  & Tomaszewski, T. et al. (2019). Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 15(3), 328-337. https://doi.org/10.5114/aic.2019.87887

Chicago

Maciejewski, Damian R, Piotr Pieniazek, Lukasz Tekieli, Piotr Paluszek, Tadeusz Przewlocki, Tomasz Tomaszewski,  and Roman Machnik et al. 2019. "Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 15 (3): 328-337. doi:10.5114/aic.2019.87887.

Harvard

Maciejewski, D., Pieniazek, P., Tekieli, L., Paluszek, P., Przewlocki, T., Tomaszewski, T., Machnik, R., Trystula, M., Legutko, J.,  and Kablak-Ziembicka, A. (2019). Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 15(3), pp.328-337. https://doi.org/10.5114/aic.2019.87887

MLA

Maciejewski, Damian et al. "Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 15, no. 3, 2019, pp. 328-337. doi:10.5114/aic.2019.87887.

Vancouver

Maciejewski D, Pieniazek P, Tekieli L, Paluszek P, Przewlocki T, Tomaszewski T et al. Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2019;15(3):328-337. doi:10.5114/aic.2019.87887.

Introduction
Drug-eluting stents of the first (DES I) and second generation (DES II) proved superior to bare metal stents (BMS) in the coronary territory. However, there are limited data on whether they have any advantage over BMS in vertebral artery stenosis (VAS).

Aim
To compare outcomes of DES (DES I, DES II) and BMS in the treatment of symptomatic extracranial VAS.

Material and methods
During 13-year study period (2003–2016), 392 consecutive patients underwent VAS angioplasty in 428 arteries, including implantation of 148 DES (DES I: 21; DES II: 127 lesions), and 280 BMS.

Results
The technical success rates for DES and BMS groups were 96.7% and 94.6% (p = 0.103), with similar periprocedural complication rates (1.4% vs. 2.2%; p = 0.565). VAS degree was reduced from 86 ±9.7 to 2.7 ±5.0% in DES (p < 0.001) and from 84.1 ±9.4 to 4.3 ±6.9% in BMS (p < 0.001). Angiography confirmed in-stent restenosis/occlusion (ISR/ISO) 50–99% in 53 (14.2%) and 21 (5.6%) out of 373 patients (409 arteries) with at least 6-month follow-up. ISR/ISO rates were similar in DES vs. BMS (22.8% vs. 19.4%; p = 0.635), as well as in DES I vs. DES II (6/19; 31.6% vs. 25/92; 27.2%, p = 0.325). Stainless steel (24/135; 17.8%) and cobalt-chromium (23/121;19%) BMS had significantly lower incidence of ISR/ISO, as compared to platinum-chromium (7/18; 38.9%), p = 0.034. ISR/ISO was associated with age (p = 0.01) and CRP level > 5 mg/l (p = 0.043), while greater stent length was associated with ISR only in the DES group (p = 0.024).

Conclusions
Our results do not support significant differences in ISR/ISO rates between DES and BMS, although differences between particular stent types and ISR rates require further investigation.

keywords:

Comparison of drug-eluting and bare metal stents for extracranial vertebral artery stenting

Damian R. Maciejewski 1 , Piotr Pieniazek 1, 2, 3 , Lukasz Tekieli 1 , Piotr Paluszek 2 , Tadeusz Przewlocki 1, 2, 3 , Tomasz Tomaszewski 4 , Roman Machnik 2 , Mariusz Trystula 2 , Jacek Legutko 1 , Anna Kablak-Ziembicka 1

drug-eluting stent, in-stent restenosis, bare metal stent, vertebral artery stenting

Damian R. Maciejewski

¹

,

Piotr Pieniazek

^{1, 2, 3}

,

Lukasz Tekieli

¹

,

Piotr Paluszek

²

,

Tadeusz Przewlocki

^{1, 2, 3}

,

Tomasz Tomaszewski

⁴

,

Roman Machnik

²

,

Mariusz Trystula

²

,

Jacek Legutko

¹

,

Anna Kablak-Ziembicka

¹