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4/2025
vol. 39 Original paper
Additive Effect of Free Walking Exercise on Liver Enzymes, Fatigue Severity, Triglycerides, and Sleeping Quality in Obstructive Sleep Apnea Patients with Non-Alcoholic Fatty Liver: Randomized Controlled Trial
Adv Rehab. 2025; 39(4): 16-27.
Online publish date: 2025/09/09
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- Ali Ismail_2025_09_24.pdf
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1. Ismail A, AbdElnabi Mousa N, Mohamed Elgendy S, Al-Emrany A, AbdelFadil Saber O, Adel Elhakk S et al. Effect of lifestyle changes on liver enzymes, triglycerides, sex hormones, and daytime sleepiness in polycystic ovarian syndrome women with obstructive sleep apnea and fatty liver – a randomized controlled trial. Menopause Review/Przegląd Menopauzalny. 2025;24(2):94-101. doi:10.5114/pm.2025.152991. 2.
Sookoian S, Pirola CJ. Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis. Obes Surg. 2013; 23(11): 1815–25. doi: 10.1007/s11695-013-0981-4. 3.
Ismail AMA, Saad AE, Draz RS. Effect of low-calorie diet on psoriasis severity index, triglycerides, liver enzymes, and quality of life in psoriatic patients with non-alcoholic fatty liver disease. Reumatologia. 2023;61(2):116–22. doi: 10.5114/reum/162995. 4.
Huang J, Chen L, Li X, Chen M, Lin T, Chen G. Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study. Nat Sci Sleep. 2023; 15: 49–57. doi: 10.2147/NSS.S398971. 5.
Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023; 78(5): 1048–62. doi: 10.1016/j.jhep.2023.01.024. 6.
Aron-Wisnewsky J, Clement K, Pépin JL. Nonalcoholic fatty liver disease and obstructive sleep apnea. Metabolism. 2016; 65(8): 1124–35. doi: 10.1016/j.metabol.2016.05.004. 7.
Kim D, Ahmed A, Kushida C. Continuous Positive Airway Pressure Therapy on Nonalcoholic Fatty Liver Disease in Patients With Obstructive Sleep Apnea. J Clin Sleep Med. 2018; 14(8): 1315–22. doi: 10.5664/jcsm.7262. 8.
Chen LD, Lin L, Zhang LJ, Zeng HX, Wu QY, Hu MF, et al. Effect of continuous positive airway pressure on liver enzymes in obstructive sleep apnea: A meta-analysis. Clin Respir J. 2018; 12(2): 373–81. doi: 10.1111/crj.12554. 9.
Ng SSS, Wong VWS, Wong GLH, Chu WCW, Chan TO, To KW, et al. Continuous Positive Airway Pressure Does Not Improve Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea. A Randomized Clinical Trial. Am J Respir Crit Care Med. 2021; 203(4): 493–501. doi: 10.1164/rccm.202005-1868OC. 10.
Jullian-Desayes I, Joyeux-Faure M, Tamisier R, aunois S, Borel AL, Levy P, et al. Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: a systematic review from sham CPAP randomized controlled trials. Sleep Med Rev. 2015; 21: 23–8. doi: 10.1016/j.smrv.2014.07.004. 11.
Ismail AMA. Virtual Reality-Based Exercise in Adolescents with Polycystic Ovarian Syndrome-Induced Fatty Liver: An Interesting and Entertaining Method Requiring More Attention. Curr Womens Health Rev 2024. doi: 10.2174/0115734048339094241106052337. 12.
Wang Y, Ai L, Luo J, Li R, Chai Y, He X, et al. Effect of adherence on daytime sleepiness, fatigue, depression and sleep quality in the obstructive sleep apnea/hypopnea syndrome patients undertaking nasal continuous positive airway pressure therapy. Patient Prefer Adherence. 2017; 11: 769–79. doi: 10.2147/PPA.S128217. 13.
Kline CE, Ewing GB, Burch JB, Blair SN, Durstine JL, Davis JM, et al. Exercise training improves selected aspects of daytime functioning in adults with obstructive sleep apnea. J Clin Sleep Med. 2012; 8(4): 357–65. doi:10.5664/jcsm.2022. 14.
Ali Ismail AM, Saad AE, Fouad Abd-Elrahman NA, Abdelhalim Elfahl AM. Effect of Benson's relaxation therapy alone or combined with aerobic exercise on cortisol, sleeping quality, estrogen, and severity of dyspeptic symptoms in perimenopausal women with functional dyspepsia. Eur Rev Med Pharmacol Sci. 2022; 26(22): 8342–50. doi: 10.26355/eurrev_202211_30367. 15.
Ismail AMA, El Gressy NSSA, Hegazy MD, Ahmed OSM, Elfahl AMA. Effects of diaphragmatic breathing exercise on sleeping quality, cortisol, cardiovascular autonomic functions, depression, and fatigue: a randomized-controlled trial in women with systemic sclerosis. Reumatologia. 2025; 63(2): 89–6. doi: 10.5114/reum/200193. 16.
Ismail AMA, Yasin FB, El-Hadidy HA, Mahany AMA, Khattab MNM, Marie KAKA, et al. Effect of pilates exercise on quality of life in patients with sickle cell disease. Electron J Gen Med. 2025; 22(4): em654. doi: 10.29333/ejgm/16229. 17.
Silva RPD, Belli KC, Carissimi A, Fiori CZ, Faria CC, Martinez D. Are there benefits of exercise in sleep apnea? Sleep Sci 2011; 4(2): 61–7. 18.
Carneiro-Barrera A, Amaro-Gahete FJ, Guillén-Riquelme A, Jurado-Fasoli L, Sáez-Roca G, Martín-Carrasco C, et al. Effect of an Interdisciplinary Weight Loss and Lifestyle Intervention on Obstructive Sleep Apnea Severity: The INTERAPNEA Randomized Clinical Trial. JAMA Netw Open. 2022; 5(4): e228212. doi: 10.1001/jamanetworkopen.2022.8212. 19.
Roche J, Gillet V, Perret F, Mougin F. Obstructive Sleep Apnea and Sleep Architecture in Adolescents With Severe Obesity: Effects of a 9-Month Lifestyle Modification Program Based on Regular Exercise and a Balanced Diet. J Clin Sleep Med. 2018; 14(6): 967–76. doi: 10.5664/jcsm.7162. 20.
da Silva RP, Martinez D, Uribe Ramos JM, Martins EF, Tedesco-Silva LM, Lopez P, et al. The effects of resistance exercise on obstructive sleep apnea severity and body water content in older adults: A randomized controlled trial. Sleep Med. 2022; 95: 37–46. doi: 10.1016/j.sleep.2022.04.014. 21.
Martins PJF, Mello MTD, Tufik S. Exercício e sono. Revista Brasileira de Medicina do Esporte. 2001; 7: 28–36. 22.
Ismail AMA, Tolba AMN. Effectiveness of lifestyle-modification approach (a randomized-controlled program of diet restriction and treadmill walking exercise) on elderly's metabolic syndrome-associated subjective tinnitus. Eur Arch Otorhinolaryngol. 2025; 282(8): 4307–15. doi:10.1007/s00405-025-09494-7. 23.
Dobrosielski DA, Patil S, Schwartz AR, Bandeen-Roche K, Stewart KJ. Effects of exercise and weight loss in older adults with obstructive sleep apnea. Med Sci Sports Exerc. 2015; 47(1): 20–6. doi:10.1249/MSS.0000000000000387. 24.
van der Windt DJ, Sud V, Zhang H, Tsung A, Huang H. The Effects of Physical Exercise on Fatty Liver Disease. Gene Expr. 2018; 18(2): 8–101. doi: 10.3727/105221617X15124844266408. 25.
Ismail AMA, Morsy MM. Effect of Baduanjin exercise on lipid profile, blood pressure, and thyroid-stimulating hormone in elderly with subclinical hypothyroidism and mild cognitive impairment: a randomized-controlled trial in women. Geriatr Nurs. 2025; 64:103434. doi:10.1016/j.gerinurse.2025.103434 26.
Sundaram SS, Halbower AC, Klawitter J, Pan Z, Robbins K, Capocelli KE, et al. Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2018; 198: 67–75.e1. doi: 10.1016/j.jpeds.2018.03.028. 27.
Ali Ismail A, El Gressy N, Hegazy M, Abdel-Halim Elfahl A, Ahmed O. Randomized controlled effect of treadmill walking exercise on liver enzymes, psychological burden, and erectile dysfunction in men with hepatitis C. Gastroenterol Rev. 2024; 19(3): 263–70. doi: 10.5114/pg.2023.130334. 28.
Hirono H, Watanabe K, Hasegawa K, Kohno M, Terai S, Ohkoshi S. Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea. World J Clin Cases. 2021; 9(19): 5112–25. doi:10.12998/wjcc.v9.i19.5112. 29.
Shpirer I, Copel L, Broide E, Elizur A. Continuous positive airway pressure improves sleep apnea associated fatty liver. Lung. 2010; 188(4): 301–7. doi: s00408-009-9219-6. 30.
Sahlman J, Seppä J, Herder C, Peltonen M, Peuhkurinen K, Gylling H, et al. Effect of weight loss on inflammation in patients with mild obstructive sleep apnea. Nutr Metab Cardiovasc Dis. 2012; 22(7): 583–90. doi: 10.1016/j.numecd.2010.10.007. 31.
Barnes M, Goldsworthy UR, Cary BA, Hill CJ. A diet and exercise program to improve clinical outcomes in patients with obstructive sleep apnea--a feasibility study. J Clin Sleep Med. 2009; 5(5): 409–15. 32.
Stadler S, Mohr A, Wagner A, Bäßler A, Fischer M, Putz FJ, et al. Weight loss induced alleviation of sleep-disordered breathing is associated with improvement of non-alcoholic fatty liver disease. Sleep Med. 2023; 112: 159–64. doi:10.1016/j.sleep.2023.10.018. 33.
Torres-Castro R, Vilaró J, Martí JD, Garmendia O, Gimeno-Santos E, Romano-Andrioni B, et al. Effects of a Combined Community Exercise Program in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial. J Clin Med. 2019; 8(3): 361. doi:10.3390/jcm8030361. 34.
Bughin F, Desplan M, Mestejanot C, Picot MC, Roubille F, Jaffuel D, et al. Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial. Sleep Med. 2020; 70: 33–42. doi:10.1016/j.sleep.2020.02.008. 35.
Schütz TC, Cunha TC, Moura-Guimaraes T, Luz GP, Ackel-D'Elia C, Alves Eda S, et al. Comparison of the effects of continuous positive airway pressure, oral appliance and exercise training in obstructive sleep apnea syndrome. Clinics (Sao Paulo). 2013; 68(8): 1168–74. doi:10.6061/clinics/2013(08)17. 36.
Yilmaz Gokmen G, Akkoyunlu ME, Kilic L, Algun C. The Effect of T'ai Chi and Qigong Training on Patients with Obstructive Sleep Apnea: A Randomized Controlled Study. J Altern Complement Med. 2019; 25(3): 317–25. doi:10.1089/acm.2018.0197. 37.
Shen HH, Xu YM, Wang N, Wang J, Ren L, Chen R. Efficacy of nasal CPAP and aerobic exercise of different intensity in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes mellitus. Zhonghua Yi Xue Za Zhi. 2019; 99(28): 2187–92. doi: 10.3760/cma.j.issn.0376-2491.2019.28.007. 38.
Ackel-D'Elia C, da Silva AC, Silva RS, Truksinas E, Sousa BS, Tufik S, et al. Effects of exercise training associated with continuous positive airway pressure treatment in patients with obstructive sleep apnea syndrome. Sleep Breath. 2012; 16(3): 723–35. doi: 10.1007/s11325-011-0567-0. 39.
Desplan M, Mercier J, Sabaté M, Ninot G, Prefaut C, Dauvilliers Y. A comprehensive rehabilitation program improves disease severity in patients with obstructive sleep apnea syndrome: a pilot randomized controlled study. Sleep Med. 2014; 15(8): 906–12. doi: 10.1016/j.sleep.2013.09.023. 40.
Jurado-García A, Molina-Recio G, Feu-Collado N, Palomares-Muriana A, Gómez-González AM, Márquez-Pérez FL, et al. Effect of a Graduated Walking Program on the Severity of Obstructive Sleep Apnea Syndrome. A Randomized Clinical Trial. Int J Environ Res Public Health. 2020; 17(17): 6334. doi: 10.3390/ijerph17176334. 41.
Borges YG, Cipriano LHC, Aires R, Zovico PVC, Campos FV, de Araújo MTM, et al. Oxidative stress and inflammatory profiles in obstructive sleep apnea: are short-term CPAP or aerobic exercise therapies effective? Sleep Breath. 2020; 24(2): 541–9. doi: 10.1007/s11325-019-01898-0.
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