Clinical immunology<br>The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA- IR) in sedentary obese women

Farzad Zehsaz; Negin Farhangi; Lamia Mirheidari

doi:10.5114/ceji.2014.45949

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2014
vol. 39

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abstract:

Clinical immunology
The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA- IR) in sedentary obese women

Farzad Zehsaz

,

Negin Farhangi

,

Lamia Mirheidari

(Centr Eur J Immunol 2014; 39 (3): 365-369)

DOI: https://doi.org/10.5114/ceji.2014.45949

Online publish date: 2014/10/14

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The purpose of the present study was to investigate the effects of a 12-week training program on serum CXC ligand 5, tumor necrosis factor α (TNF-α) and insulin resistance index in obese sedentary women. To this end, twenty-four obese sedentary women were evaluated before and after a 12-week exercise program including a brief warm-up, followed by ~45 min per session of aerobic exercise at an intensity of 60-75% of age-predicted maximum heart rate (~300 kcal/day), followed by a brief cool down, five times per week. After the exercise program, body weight, waist circumference, waist to hip ratio, percentage body fat mass, fasting glucose and insulin of participants were decreased. Furthermore, serum CXCL5 levels were significantly decreased from 2693.2 ±375.8 to 2290.2 ±345.9 pg/ml (p < 0.001) after the training program, which was accompanied with significantly decreased HOMA-IR (p < 0.001) and TNF-α (p < 0.001). Exercise training induced weight loss resulted in a significant reduction in serum CXCL5 concentrations and caused an improvement in insulin resistance in obese sedentary women.

keywords:

Clinical immunologyThe effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA- IR) in sedentary obese women

Farzad Zehsaz , Negin Farhangi , Lamia Mirheidari

CXCL5, fasting glucose, training, HOMA-IR, TNF-α

Clinical immunology
The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA- IR) in sedentary obese women

Farzad Zehsaz

,

Negin Farhangi

,

Lamia Mirheidari