Contribution of the <i>STAT4</i> rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups

HIZ M, Kılıç S, Işık S, Ogretmen Z, SIlan F. Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Central European Journal of Immunology. 2015;40(4):437-441. doi:10.5114/ceji.2015.57146.

APA

HIZ, M., Kılıç, S., Işık, S., Ogretmen, Z.,  & SIlan, F. (2015). Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Central European Journal of Immunology, 40(4), 437-441. https://doi.org/10.5114/ceji.2015.57146

Chicago

HIZ, Meliha M., Sevilay Kılıç, Selda Işık, Zerrin Ogretmen,  and Fatma SIlan. 2015. "Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups". Central European Journal of Immunology 40 (4): 437-441. doi:10.5114/ceji.2015.57146.

Harvard

HIZ, M., Kılıç, S., Işık, S., Ogretmen, Z.,  and SIlan, F. (2015). Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Central European Journal of Immunology, 40(4), pp.437-441. https://doi.org/10.5114/ceji.2015.57146

MLA

HIZ, Meliha M. et al. "Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups." Central European Journal of Immunology, vol. 40, no. 4, 2015, pp. 437-441. doi:10.5114/ceji.2015.57146.

Vancouver

HIZ M, Kılıç S, Işık S, Ogretmen Z, SIlan F. Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Central European Journal of Immunology. 2015;40(4):437-441. doi:10.5114/ceji.2015.57146.

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Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.

The aim of the study: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups.

Material and methods: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases.

Results: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients.

Conclusions: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.

keywords:

Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups

Meliha M. HIZ , Sevilay Kılıç , Selda Işık , Zerrin Ogretmen , Fatma SIlan

psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK / STAT, autoimmune thyroiditis, rs7574865

**Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups**

Meliha M. HIZ

,

Sevilay Kılıç

,

Selda Işık

,

Zerrin Ogretmen

,

Fatma SIlan