eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2014
vol. 39
 
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abstract:

Experimental immunology
Acute meningitis in rats is associated with decreased levels of miR132 and miR146a

Mubareka Jagoo
,
Fang He
,
Jing Peng
,
Fei Yin

(Centr Eur J Immunol 2014; 39 (3): 316-322)
DOI: https://doi.org/10.5114/ceji.2014.45941
Online publish date: 2014/10/14
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Introduction: The pathogenesis of bacterial meningitis due to Streptococcus pneumoniae is still unclear. Despite early treatment with antibiotics, its morbidity and mortality is still high.

Material and methods: Streptococcus pneumoniae induced rat meningitis models were taken and divided into 2 groups; control (C) and meningitis (M). Western blot was used to detect toll like receptor 4 (TLR4), tumor necrosis factor α (TNF-α), interleukin 1B (IL1B), nuclear factor κB (NFκB) and real time polymerase chain reaction were used to detect the expression of miR146a, miR132, respectively.

Results: We found that the expressions of TLR4, TNF-α, IL1B, NFκB were all up-regulated in the acute stage of bacterial meningitis when compared to the control group. While for the post transcription factors, miR146a and miR132, the opposite was observed. They were down-regulated in the meningitis group.

Conclusions: miR146a and miR132 may take part in the pathogenesis of SP bacterial meningitis as well as the TLR4- NFκB- TNF-α/IL1B signal transduction pathway.
keywords:

miR146a, miR132, bacterial meningitis, mechanism, inflammation
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