eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2020
vol. 45
 
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abstract:
Review paper

Immunonutritional support as an important part of multidisciplinary anti-cancer therapy

Karolina Kaźmierczak-Siedlecka
1
,
Agnieszka Daca
2
,
Marcin Folwarski
3
,
Wojciech Makarewicz
1
,
Anna Lebiedzińska
4

  1. Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland
  2. Department of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland
  3. Department of Clinical Nutrition and Dietetics, Medical University of Gdansk, Gdansk, Poland
  4. Department of Dietetics, Pope John Paul II State of Higher Education in Biala Podlaska, Poland
Centr Eur J Immunol 2020; 45 (4): 454-460
DOI: https://doi.org/10.5114/ceji.2020.103339
Online publish date: 2021/02/04
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Immunonutrition is one of the most important parts of nutritional treatment in patients with cancer. There are studies which confirm positive effects of using immunonutrition (arginine, glutamine, omega-3 fatty acids, nucleotides, pre- and probiotics) among others on the reduction of the pro-inflammatory cytokines concentrations, shortening of the hospital stay and improvement of the nutritional status. Arginine takes part not only in wound healing process, but also it improves body’s immunity and reduces

the incidence of infections. Glutamine reduces the incidence of acute grade 2 and 3 esophagitis and improves quality of life of gastric cancer patients. Omega 3-fatty acids have the ability to inhibit the activity of NF-B. They also reduce the symptoms of graft-versus-host disease in patients undergoing hematopoietic cell transplantation. Nucleotides support the regeneration of intestinal villi. Probiotics play many roles, mainly inhibit the process of carcinogenesis, reduce the incidence of diarrhea and modify intestinal microbiome. However, there are studies indicating the lack of advantages of using immunonutrition compared to standard nutrition. Currently, there is no clear evidence for the use of formulae enriched with immunonutrients versus standard oral nutritional supplements exclusively in the preoperative period. This review summarizes the current knowledge about the role of immunonutrition in supporting treatment of cancer diseases.
keywords:

cancer, probiotics, glutamine, omega-3 fatty acids, Immunonutrition, arginine, nucleotides
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