eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2014
vol. 39
 
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abstract:

Neutrophil extracellular traps in physiology and pathology

Aneta Manda
,
Michał P. Pruchniak
,
Magdalena Araźna
,
Urszula A. Demkow

(Centr Eur J Immunol 2014; 39 (1): 116-121)
DOI: https://doi.org/10.5114/ceji.2014.42136
Online publish date: 2014/04/22
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Neutrophil extracellular traps (NETs) are developed by nature to protect the body from furious invaders. On the other hand NETs can play an important role in human pathology. Recent studies have shown that neutrophils are able to perform beneficial suicide to create an unique microbicidal net composed from cellular content attached to chromatic frame. It is a powerful tool that primary serve as protector from severe infections, but this weapon is also a double ended sword of the immunity. If overproduced NETs provoke certain autoimmune diseases, coagulation disorders and even cancer metastases. Moreover, due to the competition between host and pathogens, the microorganism have developed a width repertoire of sophisticated evading mechanisms, like creation of polysaccharide capsule or changes in cell wall charge. Therefore it is important to increase the knowledge about paths underlying NETs formation and degradation processes if we want to efficiently fight with bacterial infections and certain diseases.
keywords:

neutrophils extracellular traps, NET in physiology and pathology, bacterial infections
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