Ragweed-allergic subjects have decreased serum levels of chemokines CCL2, CCL3, CCL4 and CCL5 out of the pollen season

Zhivka Kostova; Tsvetelina Batsalova; Dzhemal Moten; Ivanka Teneva; Balik Dzhambazov

doi:10.5114/ceji.2015.56965

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

4/2015
vol. 40

Send email

Copy url:

abstract:

Clinical immunology

Ragweed-allergic subjects have decreased serum levels of chemokines CCL2, CCL3, CCL4 and CCL5 out of the pollen season

Zhivka Kostova

,

Tsvetelina Batsalova

,

Dzhemal Moten

,

Ivanka Teneva

,

Balik Dzhambazov

(Cent Eur J Immunol 2015; 40 (4): 442-446)

DOI: https://doi.org/10.5114/ceji.2015.56965

Online publish date: 2016/01/15

View full text Get citation

PlumX metrics:

CC-chemokines are important mediators of the allergic responses and regulate the cell trafficking. The aim of this study was to examine the serum levels of CCL2/MCP-1, CCL3/MIP-1, CCL4/MIP-1 and CCL5/RANTES, and to determine whether there are differences between ragweed-allergic subjects and healthy individuals out of the pollen season. Peripheral blood samples were collected from 24 subjects allergic to ragweed pollen and 12 healthy controls. Serum concentrations of chemokines/cytokines were measured by an enzyme-linked immunosorbent assay. We observed significantly decreased concentrations of CCL2/MCP-1, CCL3/MIP-1, CCL4/MIP-1 and CCL5/RANTES in the sera of ragweed-allergic patients compared to the healthy individuals (32.2 vs. 106.4 pg/ml, 89.5 vs. 135.7 pg/ml, 63.4 vs. 119.2 pg/ml and 11.2 vs. 18.1 ng/ml, respectively, p < 0.01). In contrast to the CC-chemokines, the serum levels of IL-8/CXCL8 showed a significant increase (p < 0.05) in the allergic group compared to the non-allergic subjects. Interleukin 4 levels were similar in both groups. In the sera of allergic patients, we have also detected significantly elevated levels of ragweed-specific IgE and IgG. However, decreased serum concentrations of the four CC-chemokines and elevated levels of IL-8/CXCL8 can be used as biomarkers for more accurate evaluation of the allergic status of patients with pollen allergy out of the season, to study the mechanisms for activation/inhibition of the subclinical allergic responses and for development of therapeutic strategies.

keywords:

Ragweed-allergic subjects have decreased serum levels of chemokines CCL2, CCL3, CCL4 and CCL5 out of the pollen season

Zhivka Kostova , Tsvetelina Batsalova , Dzhemal Moten , Ivanka Teneva , Balik Dzhambazov

chemokines, IgE, pollen allergy, Ambrosia artemisiifolia, ragweed

Zhivka Kostova

,

Tsvetelina Batsalova

,

Dzhemal Moten

,

Ivanka Teneva

,

Balik Dzhambazov